How to take INTELENCE

Dosing

INTELENCE must be taken with other HIV medicines as prescribed by your healthcare professional.

The dose is two 100-mg tablets (200 mg) of INTELENCE twice a day, every day (a total of four tablets each day)
Take INTELENCE following a meal. The type of food is not important. Do not take INTELENCE on an empty stomach, as it may not work as well as it should
Swallow the tablets whole with a liquid such as water. Do not chew the tablets

If you are unable to swallow the INTELENCE tablets whole, you may place the tablets in a glass of water. Stir well until you get a milky solution. Drink the milky solution immediately. Rinse the glass with water several times, and completely swallow the rinse each time to make sure you take the entire dose

Continue taking INTELENCE unless your healthcare professional tells you to stop. Take the exact amount of INTELENCE that your healthcare professional tells you to take, right from the very start. Taking INTELENCE as prescribed and not skipping or missing doses is important.

Store INTELENCE tablets at room temperature (77°F). The temperature can range from 59°F to 86°F.

Steps to take if you skip or miss a dose of INTELENCE

If you miss a dose of INTELENCE within 6 hours of the time it is usually taken, take it following a meal as soon as possible. Then take your next dose of INTELENCE at the regularly scheduled time
If you miss a dose of INTELENCE by more than 6 hours of the time you usually take it, wait and then take the next dose of INTELENCE at the regularly scheduled time
Do not double the next dose to make up for a missed dose. Do not take more or less than your prescribed dose of INTELENCE at any one time. Always take INTELENCE following a meal
If you take too much INTELENCE, contact your local poison control center or emergency room right away

Drug Interactions

Taking INTELENCE with other medicines

Some medicines may interact with INTELENCE and may cause serious side effects or affect the levels of INTELENCE in your blood. This may increase your risk for developing resistance to INTELENCE or other HIV medicines.

Tell your healthcare professional about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements, including St. John´s wort (Hypericum perforatum).

Tell your healthcare professional if you take other HIV medicines. INTELENCE can be combined with most HIV medicines, but some HIV medicines are not recommended (see chart).

Medicines that should not be taken with INTELENCE

Brands listed are registered trademarks of their respective owners.

Other medicines can be taken with INTELENCE — many without changing the dose of either medicine.

This is not a complete list of medicines that you should tell your healthcare professional about. It may be helpful to keep a list of all the medicines you take. Show this list to all of your healthcare professionals and pharmacists any time you get a new medicine. They can tell you if these other medicines can be taken with INTELENCE.

Do not start any new medicines while taking INTELENCE without first talking to your healthcare professional or pharmacist. You can ask them for a complete list of medicines that can interact with INTELENCE.

Refer to the full Product Information on this Web site for more information on medicines that can and cannot be taken with INTELENCE. Remember, your healthcare professional is your most important resource while taking INTELENCE.

About INTELENCE

INTELENCE is a prescription HIV medicine that helps to control HIV (human immunodeficiency virus) infection in adults. INTELENCE is a type of anti-HIV medicine called a non-nucleoside reverse transcriptase inhibitor (NNRTI), also known as a non-nuke

INTELENCE must be taken in combination with other HIV medicines. INTELENCE is for patients who are already taking or have taken HIV medicines, have resistance to non-nukes and other HIV medicines and whose HIV infection is not under control
- The use of other medicines active against your HIV in combination with INTELENCE may increase the likelihood of your overall treatment response. If a non-nuke regimen has stopped working for you, INTELENCE should not be taken with only nucleoside/nucleotide reverse transcriptase inhibitors, also known as nukes. Your healthcare professional will work with you to find the right combination of other HIV medicines
- It is important that you remain under the care of your healthcare professional during treatment with INTELENCE

The safety and effectiveness of INTELENCE have not been studied in children or patients who have never taken HIV medications before

INTELENCE does not cure HIV infection or AIDS, and does not prevent passing HIV to others.

Ask your healthcare professional if INTELENCE is right for you

Important Safety Information
What are the possible side effects of INTELENCE?

Skin rash is a common side effect of INTELENCE. Rash can be serious and potentially life-threatening. Contact your healthcare professional right away if you get a rash. Your healthcare professional will decide if INTELENCE must be stopped

Patients taking INTELENCE may have severe skin rashes or rashes with an allergic reaction (hypersensitivity reactions). Sometimes these allergic reactions can affect body organs, like the liver. These allergic reactions usually include a rash with other symptoms such as fever, generally ill feeling, extreme tiredness, muscle or joint aches, blisters, oral sores, irritated eyes, facial swelling, swelling of eyes, lips, or mouth, breathing difficulty, and/or signs and symptoms of liver problems (eg, yellowing of your skin or whites of your eyes, dark or tea- colored urine, pale colored stools/bowel movements, nausea, vomiting, loss of appetite, or pain, aching or sensitivity on your right side below your ribs)
If you get a rash, contact your healthcare professional right away to determine if you should stop taking INTELENCE

What should I tell my doctor before I take INTELENCE?

Before taking INTELENCE, tell your healthcare professional if you have any medical conditions such as liver problems (including hepatitis B or C) or if you are pregnant, planning to become pregnant, or breastfeeding

The effects of INTELENCE on pregnant women are not known. It is not known if INTELENCE can cause harm to your unborn baby. You and your healthcare professional will need to decide if taking INTELENCE is right for you

Do not breastfeed if you are taking INTELENCE. You should not breastfeed if you have HIV because of the chance of passing HIV to your baby

Can INTELENCE be taken with other medicines?

Taking INTELENCE with certain medicines could cause side effects or may result in loss of its effectiveness (which could increase your risk for developing resistance to INTELENCE or other HIV medicines). Do not take INTELENCE if you are taking the following medicines:

HIV: tipranavir/ritonavir (Aptivus^®), fosamprenavir/ritonavir (Lexiva^®), atazanavir/ritonavir (Reyataz^®), full-dose ritonavir (Norvir^® 600 mg twice a day), unboosted protease inhibitors (without ritonavir), nevirapine (Viramune^®), efavirenz (Sustiva^®), or delavirdine (Rescriptor^®)
Other: carbamazepine (Tegretol^®, Carbatrol^®), phenobarbital (Luminal^®), phenytoin (Dilantin^®, Phenytek^®), rifabutin (Mycobutin^®), rifampin (Rifadin^®, Rifater^®, Rifamate^®), rifapentine (Priftin^®), or products containing St. John's wort (Hypericum perforatum)

Before starting INTELENCE, tell your healthcare professional about all medicines you are taking or plan to take, including prescription and nonprescription medicines, vitamins, and herbal supplements. Please see full product information for more details

What are the possible side effects of INTELENCE? (continued)

As with other HIV medicines, INTELENCE may cause side effects, including:

Changes in body shape or body fat. The cause and long-term health effects of these conditions are not known at this time

Immune reconstitution syndrome. Signs and symptoms of inflammation from opportunistic infections that a person has or had may occur as the medicines work to control the HIV infection and strengthen the immune system. Call your healthcare professional right away if you experience any signs or symptoms of an infection

Other common side effects of INTELENCE include tingling or pain in hands or feet, and numbness

This is not a complete list of all side effects. If you experience these or other symptoms, contact your healthcare professional right away. Do not stop taking INTELENCE or any other medications without first talking to your healthcare professional.

You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see the full Product Information in PDF format for more details.

© Tibotec Therapeutics, Division of Centocor Ortho Biotech Products, L.P. 2010. All rights reserved.

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Tibotec Therapeutics, Division of Centocor Ortho Biotech Products, L.P., which is solely responsible for its contents.

The material on this site is intended only as informational or as an educational aid and it is not intended to be taken as medical advice. The ultimate responsibility for patient care resides with a healthcare professional.

This information is intended for the use of our customers, patients, and healthcare professionals in the United States only. Laws, regulatory requirements, and medical practices for pharmaceutical products vary from country to country. The Prescribing Information included here may not be appropriate for use outside the United States.

INTELENCE is a trademark of Tibotec Pharmaceuticals, Ltd.

This site was last updated on: March 10 2010 at 8:40 EDT.